Research & Initiatives
The Corti Lab is focused on an urgent human need related to neurological diseases
Corti lab is focused on cellular (stem cells) and molecular therapies (gene therapies, antisense oligonucleotides) for neurodegenerative diseases in particular motor neuron diseases (Amyotrophic Lateral Sclerosis, ALS, Spinal Muscular Atrophy, SMA, Spinal Muscular Atrophy with Respiratory Distress type 1, SMARD1), neuropathies (CMT2A) and neuromuscular diseases.
We established patient-specific 2D and 3D models (iPSC-derived organoids patterned into brain/spinal cord) to study disease pathogenesis and develop novel therapeutic strategies for neurological diseases.
Neurodegenerative diseases are highly disabling and fatal disorders, often without a cure, that place a huge burden on patients and their families and have a significant impact on society. There is urgent need to find effective treatment for these conditions.
Our research is focused on studying all aspects of neurodegenerative diseases like spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS).
Our group creates synergistic, programs for target discovery and functional analysis in an intellectual, collegial and stimulating environment.
University of Milan and Foundation IRCCS Ca' Granda offer an unparalleled location for this initiative because it currently houses, in close proximity, world-class research and clinical groups. These include scientists engaged in the study of neuronal function, relevant aspects of stem cell biology and in vitro and in vivo models of human diseases. These scientists work with internationally renowned clinicians experienced in clinical trials for neurological diseases, committed to apply into their programs the latest findings from basic research and able to provide advice about the feasibility of therapeutic approaches for humans.